null

SMILES CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1

InChI Key InChIKey=BPQMGSKTAYIVFO-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 50249522   

TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKi:  16.2nMAssay Description:Displacement of [3H]cyclopamine from wild type Smo expressed in U2OS cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6QMJPubMed
TargetAlbumin(Homo sapiens (Human))
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  1.30E+5nMAssay Description:Binding affinity to high-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMedDrugBank
TargetAlbumin(Rattus norvegicus)
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  1.40E+5nMAssay Description:Binding affinity to rat serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMed
TargetAlbumin(Rattus norvegicus)
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  1.71E+5nMAssay Description:Binding affinity to high-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMed
TargetSonic hedgehog protein(Homo sapiens (Human))
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assay i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMed
TargetAlbumin(Homo sapiens (Human))
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to human serum albumin at 20 degC by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMedDrugBank
TargetAlbumin(Rattus norvegicus)
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  5.80E+3nMAssay Description:Binding affinity to low-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMed
TargetAlbumin(Homo sapiens (Human))
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to low-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMedDrugBank
TargetSonic hedgehog protein(Homo sapiens (Human))
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human SHH pathway in mouse S12 cells assessed as GLI-mediated transcriptional activity after 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMed
TargetAlbumin(Homo sapiens (Human))
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  1.20E+5nMAssay Description:Binding affinity to human serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0V6GPubMedDrugBank
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at Smo in mouse Shh-Light 2 cells assessed as inhibition of Shh-induced Gli1-reporter activity after 2 days by dual-luciferase re...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of smoothened (unknown origin)-mediated Shh signalingMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Antagonist activity at smoothened (unknown origin) expressed in mouse Shh Light2 cells co-expressing Gli-dependent reporter gene assessed as inhibiti...More data for this Ligand-Target Pair
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 7.20nMAssay Description:Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49S7WPubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of SHH in mouse Shh Light2 cells by GLI-responsive firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N536MPubMed
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of Smo in mouse C3H10T1/2 cells using human recombinant SHH assessed as effect on SMO/SHH transient transcriptional activation after 20 hr...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of BODIPY-labelled cyclopamine from human Smo receptor expressed in HEK293 cells after 2 hrs by fluorescence microscopyMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of Smo-mediated Hh signaling in human Shh-light2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of Smo-mediated Hh signalling pathway in mouse Shh Light2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Antagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated ...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GR...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Antagonist activity at Smo receptor in mouse NIH/3T3 cells harboring GRE-Luc assessed as inhibition of SAG-induced Hh signaling pathway preincubated ...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Displacement of BODIPY-Cyclopamine from human HA-tagged Smo receptor expressed in human U2OS cells at 1 to 10000 nM incubated for 2 hrs by DAPI stain...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataEC50:  4.70nMAssay Description:Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentia...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataEC50:  2nMAssay Description:Binding affinity to human SMOMore data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataEC50: <0.100nMAssay Description:Binding affinity to mouse SMOMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMedDrugBank
TargetCytochrome P450 2D6(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMedDrugBank
TargetCytochrome P450 2C19(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMedDrugBank
TargetCytochrome P450 1A2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataEC50:  3nMAssay Description:Displacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataEC50:  2nMAssay Description:Displacement of BODIPY-labeled cyclopamine from mouse SMO transfected in human HeLa cells by competition binding assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of SMO D473H mutant receptor (unknown origin) assessed as inhibition of SAG-induced Hh signaling pathway by Gli luciferase reporter cell-b...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataKd:  97.5nMAssay Description:Binding affinity to recombinant human Smo receptor assessed as dissociation constant at equilibrium by SPR analysisMore data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Antagonist activity at SMO in mouse NIH3T3 cells preincubated for 2 hrs followed by SAG stimulation and measured after 24 hrs by Bright-Glo luciferas...More data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of Smo receptor (unknown origin) expressed in NIH3T3 cells assessed as inhibition of Smo agonist SAG-induced GRE activation after 30 hrs b...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of SMO in mouse NIH/3T3 cells assessed as inhibition of SAG-induced hedgehog-mediated luminescence signaling by GRE-luciferase reporter ge...More data for this Ligand-Target Pair