null

SMILES OC(=O)[C@]1(Cc2cccc(Nc3nccs3)n2)CCC(CC1)Oc1cccc(Cl)c1F

InChI Key InChIKey=LCVIRAZGMYMNNT-CWISFOPVSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 109209   

TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM109209(VX-689)copy SMILEScopy InChI
Affinity DataKi:  0.0155nM ΔG°:  -15.0kcal/mole IC50: 3.88nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A/Targeting protein for Xklp2 [1-43](Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM109209(VX-689)copy SMILEScopy InChI
Affinity DataKi:  2.17nM ΔG°:  -12.0kcal/mole IC50: 2.07E+3nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM109209(VX-689)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM). Subseque...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed