null
SMILES [H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3c2[C@]1(C)[C@@H](COC)OC3=O
InChI Key InChIKey=QDLHCMPXEPAAMD-QAIWCSMKSA-N
PDB links: 4 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 63 hits for monomerid = 15234
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of DNA-PK isolated from human HeLa cell extractMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of human recombinant p110 alpha Phosphatidylinositol 3-kinaseMore data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Binding affinity for DNA dependent protein kinase isolated from HeLa cells; Range is 20-120More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nM ΔG°: -7.86kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
Affinity DataKi: 2.80E+3nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
TargetEndoribonuclease toxin MazF(Escherichia coli str. K-12 substr. MG1655)
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Affinity DataEC50: >9.90E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
TargetEndoribonuclease toxin MazF(Escherichia coli str. K-12 substr. MG1655)
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Affinity DataEC50: >9.90E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
Burnham Center for Chemical Genomics
Curated by PubChem BioAssay
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
The University of Jordan
Curated by ChEMBL
The University of Jordan
Curated by ChEMBL
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as decrease in fluorescence intensity using phosphorylated substrateMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against MTORMore data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of AX7503 binding to recombinant Plk3 (unknown origin) expressed in HeLa cells by Western blotMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of AX7503 binding to recombinant Plk1 (unknown origin) by Western blotMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant Plk3 (unknown origin) assessed as casein substrate phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of Plk3 in human A549 cells assessed as casein substrate phosphorylation by western blotMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataIC50: 17.6nMAssay Description:Inhibition of PI3K (unknown origin) by fluorescence energy transfer assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University of New York-ESF
Curated by ChEMBL
State University of New York-ESF
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human PI3KdeltaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human PI3KbetaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PI3KalphaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
The University of Jordan
Curated by ChEMBL
The University of Jordan
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3 kinaseMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
University of Dundee
Curated by ChEMBL
University of Dundee
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of chicken SmMLCK expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human p110alpha PI3K fragment by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human PI3K p110beta catalytic subunit by AlphaScreen competition assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
The University of Jordan
Curated by ChEMBL
The University of Jordan
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of human PI3K p110gamma catalytic subunit by AlphaScreen assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human PI3K p110delta catalytic subunit by AlphaScreen assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase (mMLCK)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University of New York-ESF
Curated by ChEMBL
State University of New York-ESF
Curated by ChEMBL
Affinity DataIC50: 11.9nMAssay Description:Inhibition of human recombinant P110alpha/p85alpha using phosphatidyl inositol as substrate after 1 hr by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University of New York-ESF
Curated by ChEMBL
State University of New York-ESF
Curated by ChEMBL
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of PI3K p110alpha/p85alpha (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PLK1 in the presence of 5uM ATPMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SmMLCK in the presence of 50uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of GST-tagged Plk1 using recombinant protein X as a substrate containing threonine residuesMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
The University of Jordan
Curated by ChEMBL
The University of Jordan
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3KgammaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 4.61E+4nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.32E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataKd: 9.20E+3nMAssay Description:Binding affinity to human mTOR after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKd: 5.5nMAssay Description:Binding affinity to human PI3Kdelta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
The University
Curated by ChEMBL
The University
Curated by ChEMBL
Affinity DataKd: 5.40nMAssay Description:Binding affinity to human PI3Kalpha after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
The University of Jordan
Curated by ChEMBL
The University of Jordan
Curated by ChEMBL
Affinity DataKd: 15nMAssay Description:Binding affinity to human PI3Kgamma after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Serono Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKd: 7.60nMAssay Description:Binding affinity to human PI3Kbeta after 1 hr by KINOMEscan assayMore data for this Ligand-Target Pair