null

SMILES COC1(CCOCC1)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1

InChI Key InChIKey=SLZBEPLWGGRZAY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50000829   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Centre de Recherches

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of 5-lipoxygenase from human whole bloodMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JW8CZPPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V01PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Centre de Recherches

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V01PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Centre de Recherches

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7B16PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Centre de Recherches

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of leukotriene B4 synthesis in human whole blood by inhibiting 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q240VJPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Centre de Recherches

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639QCJPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Université de Lille 2

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2V01PubMed