null

SMILES Cc1noc(=O)c2ccc(NC(=O)C(O)(CC(C)(C)c3cccc4CCOc34)C(F)(F)F)cc12

InChI Key InChIKey=VRZVKIJRJRBQJT-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50201099   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of tetramethylrhodamine labeled dexamethosone binding to GR by FP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2PTBPubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of tetramethylrhodamine labeled dexamethosone binding to MR by FP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2PTBPubMed
TargetProgesterone receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of tetramethylrhodamine labeled RU486 binding to PR by FP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2PTBPubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 6.31nMAssay Description:Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human HeLa cells assessed as inhibition of TPA-induced coll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974V3PubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataEC50:  12.6nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells assessed as induction of MMTV promoter activity by luciferase reporter gene a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974V3PubMed
TargetProgesterone receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 19.9nMAssay Description:Binding affinity to human recombinant progesterone receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974V3PubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 79.4nMAssay Description:Binding affinity to human recombinant mineralocorticoid receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974V3PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Bayer Schering Pharma AG

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 631nMAssay Description:Binding affinity to human recombinant androgen receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974V3PubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 31.6nMAssay Description:Transrepression activity at glucocorticoid receptor-mediated antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced IL-8...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974V3PubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201099(4-(2,3-dihydrobenzofuran-7-yl)-2-hydroxy-4-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 19.9nMAssay Description:Binding affinity to human recombinant glucocorticoid receptor expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26974V3PubMed