null

SMILES OC(=O)Cn1c2cc(Cl)ccc2c(=O)n(Cc2ccc(Br)cc2F)c1=O

InChI Key InChIKey=SXONDGSPUVNZLO-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 16496   

TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 9.90E+3nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38QSNPubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 42.4nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute for Diabetes Discovery

LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of aldose reductaseMore data for this Ligand-Target Pair