null
SMILES CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)OCCCc1cccnc1
InChI Key InChIKey=OQAHHWOPVDDWHD-INIZCTEOSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 23334
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataKi: 0.0100nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
Affinity DataKi: 7.5nM ΔG°: -10.1kcal/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataKi: 7.5nMAssay Description:The compound was tested for binding affinity against rotamaseMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataKi: 7.5nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
In DepthDetails
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity to FKBP52 FK1 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity to FKBP51 FK1 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.09E+4nMAssay Description:The inhibitory activity by using FK506 binding protein 12 SPA binding assayMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Guilford Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 1.24E+3nMAssay Description:Binding affinity to FKBP12 by fluorescence polarization assayMore data for this Ligand-Target Pair