null

SMILES c1cnc2c(c1)ccc1cccnc21

InChI Key InChIKey=DGEZNRSVGBDHLK-UHFFFAOYSA-N

PDB links: 10 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50092158   

TargetGalanin receptor type 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Florida Research Institute, TSRI Assay...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2D21W05PCBioAssay
TargetCollagenase 3 (MMP13)(Homo sapiens (Human))TBA
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
TargetRecBCD enzyme subunit RecD(Escherichia coli str. K-12 substr. MG1655)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 3.05E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15CWPCBioAssay
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0M3VUS Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0M3VUS Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 9.00E+3nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0M3VUS Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0M3VUS Patent
TargetCollagenase 3 (MMP13)(Homo sapiens (Human))TBA
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0M3VUS Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+6nMAssay Description:Inhibition of [3H]-farnesyl pyrophosphate binding to human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QZ29BRPubMed
TargetVIM-1 protein(Pseudomonas aeruginosa)
Hospital Son Dureta

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa VIM-1 beta-lactamase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ1186PubMed
TargetVIM-13(Pseudomonas aeruginosa)
Hospital Son Dureta

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 6.93E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa VIM-13 beta-lactamase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ1186PubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 7.40E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataEC50:  5.01E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataEC50:  6.31E+3nMAssay Description:Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataEC50:  3.90E+3nMAssay Description:Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataEC50:  5.90E+3nMAssay Description:Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 7.94E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataEC50:  4.90E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataEC50:  3.98E+3nMAssay Description:Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81F7SPubMed
TargetSnake venom metalloproteinase neuwiedase(Bothrops pauloensis)
Instituto de Ci£ncias Exatas

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.70E+5nMAssay Description:Inhibition of Bothrops pauloensis MP1 assessed as reduction in azocaseinolytic activity after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85DKPubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Osaka Organic Chemical Industry, Ltd

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 minMore data for this Ligand-Target Pair
TargetCollagenase ColG(Clostridium histolyticum)
Osaka Organic Chemical Industry, Ltd

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of Clostridium histolyticum collagenase after 15 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G163RPPubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
Osaka Organic Chemical Industry, Ltd

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.22E+5nMAssay Description:Inhibition of Bos taurus (bovine) pancrease carboxypeptidase A after 15 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G163RPPubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 2.25E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 9.00E+3nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent
TargetCollagenase 3 (MMP13)(Homo sapiens (Human))TBA
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 2.25E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 9.00E+3nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
TargetGalanin receptor type 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute (TSRI) Assay Provid...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W094B7PCBioAssay