null

SMILES CN(C)CCCN1c2ccccc2Sc2ccccc12

InChI Key InChIKey=ZGUGWUXLJSTTMA-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 67545   

TargetHistamine H1 receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065JHPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7G5BPubMedDrugBank
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  5.88nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065JHPubMedDrugBank
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7G5BPubMedDrugBank
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  15.9nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065JHPubMedDrugBank
TargetHistamine H1 receptor(RAT)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  30nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN14P6PubMed
TargetD(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  71.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7M9VPubMed
TargetD(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  72nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WH6PubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  149nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065JHPubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7G5BPubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
ACADIA Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  159nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MNBPubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  160nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7G5BPubMedDrugBank
TargetD(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  161nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065JHPubMedDrugBank
TargetD(2) dopamine receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  300nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60MNBPubMedDrugBank
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  900nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7G5BPubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  909nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065JHPubMed
TargetD(1A) dopamine receptor(BOVINE)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  7.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WH6PubMed
TargetD(1A) dopamine receptor(BOVINE)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  7.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7M9VPubMed
Target5-hydroxytryptamine receptor 1A/1B/1D/2C(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065JHPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZK5F5PPubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataKi:  5.91E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP457XPubMed
TargetGlutathione S-transferase P/Mucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH)

US Patent
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 5.80E+3nMT: 2°CAssay Description:To screen for small molecular weight compounds that can inhibit MALT1 protease activity, recombinant GSTMALT1 was purified from E. coli to establish ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21C1VSRUS Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 4.71E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetMajor prion protein(Homo sapiens (Human))
Institut f£r Molekularbiologie und Biophysik

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataEC50:  5.00E+3nMAssay Description:Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cellsMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
Mayo Clinic and Foundation

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 2.45E+3nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17BZPubMedDrugBank
TargetHistamine H1 receptor(RAT)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17BZPubMed
TargetNADPH oxidase 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+4nMAssay Description:Data Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institut...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK998GPCBioAssay
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23779MDPubMed
TargetPleiotropic ABC efflux transporter of multiple drugs(Saccharomyces cerevisiae S288c)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125TNZPubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Compound was tested for inhibition of [3H]spiperone binding in membrane preparations obtained from calf caudate.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21C203TPubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 1.04E+3nMAssay Description:Compound was tested for inhibition of [3H]spiperone binding in membrane preparations obtained from rat corpus striatum.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21C203TPubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z321T8PubMed