null
SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc1cc(O)ccc31
InChI Key InChIKey=VWUXBMIQPBEWFH-WCCTWKNTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 50169743
Affinity DataKi: 1.04nMAssay Description:In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataKi: 1.39nMAssay Description:In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor betaMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Competitive inhibition of human recombinant soluble epoxide hydrolase using [3H]-tDPPO as substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.209nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Agonist activity at progesterone receptor in human MCF7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0631nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.813nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]17-beta-estradiol from human Estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:Antagonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 44.1nMAssay Description:Binding affinity to human ERbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Binding affinity to human ERalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 5.89nMAssay Description:Displacement of [3H]estradiol from rat uterine cytosolic estrogen receptorMore data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase using (cyano(6-methoxy-naphthelen-2-yl)methyl trans-[(3-phenyl-oxiran-2-yl)methyl] carbonat...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
City of Hope National Medical Center
Curated by ChEMBL
City of Hope National Medical Center
Curated by ChEMBL
Affinity DataEC50: 1.95E+3nMAssay Description:Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase re...More data for this Ligand-Target Pair
Affinity DataIC50: 790nMAssay Description:Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetSteroid hormone receptor ERR1(Homo sapiens (Human))
University of Kansas Medical Center
Curated by ChEMBL
University of Kansas Medical Center
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cells assessed as inhibition of cell growth after 6 days by crystal violet staining methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at estrogen receptor alpha ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luc...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at estrogen receptor beta ligand binding domain expressed in african green monkey COS7 cells co-transfected with Gal4-LBD by luci...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at ERalpha in human MCF7 cells assessed as inhibition of estrogen-induced transcription preincubated overnight followed by estrog...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 18 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as inhibition of insulin-mediated cell proliferation after 6 days by Hoechst 33258 dye-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:MCF-7 cells were adjusted to a concentration of 40,000 cells per mL in RPMI containing 10% FBS and 20 mM HEPES. 16 microliters of the cell suspension...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [3H]-E2 from estrogen receptor-beta (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human estrogen receptor 2 using tritiated estradiol incubated for 3 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]-E2 from estrogen receptor-alpha (unknown origin) by scintillation counting analysisMore data for this Ligand-Target Pair