null
SMILES CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12
InChI Key InChIKey=MFWNKCLOYSRHCJ-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 38 hits for monomerid = 50000483
Affinity DataKi: 0.251nMAssay Description:Displacement of [3H]granisetron from 5-hydroxytryptamine 3 receptor of rat cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.589nMAssay Description:Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heartMore data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Binding affinity for central 5-hydroxytryptamine 3 receptor was determined by displacement of [3H]-ketanserinMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.45nMAssay Description:Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.45nMAssay Description:Displacement of [3H]granisetron from human 5HT3A expressed in HEK293 cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-a...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:In vitro by displacement of [3H]LY-278584 from 5-hydroxytryptamine 3 receptor on rat entorhinal cortexMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Compound was evaluated for its ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15. More data for this Ligand-Target Pair
Affinity DataKi: 3.98nMAssay Description:Binding affinity to 5HT3A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 9.10nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagusMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Lilly Research Laboratories
Curated by ChEMBL
Lilly Research Laboratories
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1B receptor in rat cortical membranes using [3H]5-HT as a radioligandMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 2 receptor in rat cortical membranes using [3H]ketanserin as a radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Lilly Research Laboratories
Curated by ChEMBL
Lilly Research Laboratories
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1A receptor in rat cortical membranes using [3H]8-OH-DPAT as a radioligandMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-a...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Lilly Research Laboratories
Curated by ChEMBL
Lilly Research Laboratories
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1C receptor in rat cortical membranes using [3H]mesulergine as a radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by PDSP Ki Database
National Institute of Neurological Disorders and Stroke
Curated by PDSP Ki Database
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by PDSP Ki Database
National Institute of Neurological Disorders and Stroke
Curated by PDSP Ki Database
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for central 5-hydroxytryptamine 3 receptor was determined by displacement of [3H]GR-65630More data for this Ligand-Target Pair
Affinity DataKi: <1.00E+4nMAssay Description:5-hydroxytryptamine 3 receptor antagonist activity was confirmed by its ability to antagonize 5-HT evoked tachycardia of rabbit isolated heartMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:In vitro Binding affinity towards alpha-7 nAChR was determinedMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataKi: 3.80E+4nMAssay Description:In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determinedMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataKi: 6.70E+4nMAssay Description:In vitro Binding affinity towards 5-hydroxytryptamine 3 receptor was determinedMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.
Curated by ChEMBL
TCG Lifesciences Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+3nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Mus musculus (house mouse))
Merrell Dow Research Institute
Curated by ChEMBL
Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKd: 1.40nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Mus musculus (house mouse))
Merrell Dow Research Institute
Curated by ChEMBL
Merrell Dow Research Institute
Curated by ChEMBL
Affinity DataKd: 1.30nMAssay Description:Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity towards 5-HT3 receptor in rat was evaluatedMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.
Curated by ChEMBL
TCG Lifesciences Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
TargetMultidrug and toxin extrusion protein 2(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 3.11E+5nMAssay Description:Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.
Curated by ChEMBL
TCG Lifesciences Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.73E+3nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TCG Lifesciences Ltd.
Curated by ChEMBL
TCG Lifesciences Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair