null

SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1

InChI Key InChIKey=UAWXGRJVZSAUSZ-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50038649   

Target5-lipoxygenase(Bos taurus)
Merckle GmbH

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of 5-lipoxygenase in bovine PMNL cell assay.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8Z2HPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsomal membrane assessed as blockade of PGH2 to PGE2 conversion after 1 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6XGXPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsomal membrane assessed as residual enzyme activity after 1 min by measuring PGE2 level...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6XGXPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition constant against arachidonate 5-lipoxygenase More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SF2WZ9PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SF2WZ9PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibitory concentration against prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SF2WZ9PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of mPGES1 in LPS-stimulated human whole blood assessed as reduction in PGE2 production incubated for 24 hrs at 37 degC by enzyme immunoass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20P115JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of mPGES1 expressed in Escherichia coli Rosetta-DE3 assessed as reduction in PGE2 production by enzyme immunoassay based cell-free system ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20P115JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL2-DE3 incubated 10 mins before substrate addition by fluorescence spectrophotom...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20P115JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Peking University

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of 5-LOX in rat RBL1 cells assessed as reduction in LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20P115JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibition of 5-LOX (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DTPPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as decrease in 5-HPETE production preincubated with enzyme followed...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639RRWPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataEC50:  100nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in PGE2 productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639RRWPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639RRWPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of mPGES1 in human HeLa cells assessed as reduction in TNF-alpha induced PGE2 production preincubated for 2 hrs followed by TNF-alpha addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639RRWPubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of bovine COX1 assessed as inhibition of calcium ionophore A23187-induced 12-hydroxyheptadecatrienoic acid formation by reverse-phase HPLC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90GCPubMed
Target5-lipoxygenase(Bos taurus)
Merckle GmbH

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 760nMAssay Description:Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotrine B4 formation by reversed phase HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P90GCPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Non noncompetitive inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92DRPPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92DRPPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 9.85E+3nMAssay Description:Inhibition of human COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C722KPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C722KPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 510nMAssay Description:Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 10...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C722KPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3R2WPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EI...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3R2WPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 210nMMore data for this Ligand-Target Pair
In DepthDetails
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 4.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 180nMMore data for this Ligand-Target Pair
In DepthDetails
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of human 5-lipoxygenase in human cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8Z2HPubMed