null
SMILES Oc1cccc2cccnc12
InChI Key InChIKey=MCJGNVYPOGVAJF-UHFFFAOYSA-N
PDB links: 3 PDB IDs match this monomer. 6 PDB IDs contain this monomer as substructures. 6 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 32203
Affinity DataKi: 2.14E+5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University Molecular Libraries Screening Center
Curated by PubChem BioAssay
Emory University Molecular Libraries Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
TargetFructose-bisphosphate aldolase(Mycobacterium tuberculosis (strain H37Rv))
The University of Denver and Regis University
US Patent
The University of Denver and Regis University
US Patent
Affinity DataIC50: 3.00E+5nMAssay Description:Enzymatic activity is measured by contacting the enzyme with a suitable substrate, such as fructose 1,6-bisphosphate, and measuring formation of a pr...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+5nMAssay Description:Inhibition of human recombinant MMP2 after 30 minsMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
ActivX Biosciences, Inc.
Curated by ChEMBL
ActivX Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human plasma lipoprotein-associated phospholipase A2 using 2-thio-PAF as substrate preincubated for 20 mins measured 1 hr post substrat...More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
ActivX Biosciences, Inc.
Curated by ChEMBL
ActivX Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human plasma lipoprotein-associated phospholipase A2 using 2-thio-PAF as substrate preincubated for 20 mins measured 1 hr post substrat...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Clostridium botulinum BoNT/A LC expressed in Escherichia coli assessed as cleavage of SNAPtide preincubated for 5 mins followed by SNAP...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Institute for Cancer Research
Curated by ChEMBL
Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 7.50E+5nMAssay Description:Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AIMore data for this Ligand-Target Pair
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of human MetAP1More data for this Ligand-Target Pair
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of recombinant full length human His-tagged methionine aminopeptidase 1 expressed in Escherichia coli BL21(DE3) using methionylprolyl-p-ni...More data for this Ligand-Target Pair
Affinity DataIC50: 1.27E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST/His6-tagged methionine aminopeptidase 2 expressed in baculovirus infected sf9 cells using ...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of protease activity of recombinant full length Clostridium botulinum Hall BoNT/A light chain using SNAP-25 peptide (187 to 203 residues) ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
University of California San Diego
Curated by ChEMBL
University of California San Diego
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
University of California San Diego
Curated by ChEMBL
University of California San Diego
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:Antibacterial activity against Enterococcus faecalis MTCC 439 incubated overnight by broth dilution techniqueMore data for this Ligand-Target Pair
Affinity DataEC50: 1.11E+4nMAssay Description:Substrate-dependent activation of HDAC8 (unknown origin) using FLUOR DE LYS as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of human methionine aminopeptidase 2More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human methionine aminopeptidase 1More data for this Ligand-Target Pair