null
SMILES CONC(=O)Nc1ccc(cc1)-c1sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccc3)c(=O)c2c1CN(C)Cc1ccccc1
InChI Key InChIKey=UCQSBGOFELXYIN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 99 hits for monomerid = 50122654
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182EMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S124AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203EMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309LMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y283FMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27EMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR W291FMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186DMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 192nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.07E+3nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118NMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from human wild type GnRHRMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 24.4nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F313LMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203PMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302NMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 4.30nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305DMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208EMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111QMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 148nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302QMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 242nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112FMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 193nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24TMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295QMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284FMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 94.9nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306EMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 12.1nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284LMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189PMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR A50TMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111AMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208DMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293NMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300VMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189EMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR T190KMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 108nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24IMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S203QMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168IMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309QMore data for this Ligand-Target Pair