null
SMILES CC(=O)CC(c1ccccc1)c1c(O)c2ccccc2oc1=O
InChI Key InChIKey=PJVWKTKQMONHTI-UHFFFAOYSA-N
PDB links: 3 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50343352
TargetSolute carrier organic anion transporter family member(Danio rerio (Zebrafish))
Rudjer Boskovic Institute
Rudjer Boskovic Institute
Affinity DataKi: 360nMAssay Description:In the inhibition experiments, the cells were preincubated for 20 s with test compounds, followed by a 5-min incubation with [3H]E3S (5 nM) or 30-min...More data for this Ligand-Target Pair
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Affinity DataKi: 600nM ΔG°: -8.82kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Affinity DataKi: 1.80E+3nM ΔG°: -8.15kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Binding affinity towards cytochrome P450 2C9More data for this Ligand-Target Pair
TargetVitamin K epoxide reductase complex subunit 1-like protein 1(Rattus norvegicus (Rat))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Affinity DataKi: 3.26E+4nM ΔG°: -6.36kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
TargetVitamin K epoxide reductase complex subunit 1-like protein 1(Homo sapiens (Human))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Affinity DataKi: 5.20E+4nM ΔG°: -6.08kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
Affinity DataKd: 1.20E+4nMAssay Description:Binding affinity to human serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 9.50E+4nMAssay Description:Binding affinity to rat serum albumin at 37 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetProprotein convertase subtilisin/kexin type 7(Homo sapiens (Human))
Universidade Estadual Paulista
Curated by ChEMBL
Universidade Estadual Paulista
Curated by ChEMBL
Affinity DataIC50: 2.46E+4nMAssay Description:Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubat...More data for this Ligand-Target Pair
Affinity DataKd: 4.68E+3nMAssay Description:Binding affinity to human serum albumin by PAMPA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.15E+5nMAssay Description:Tested in vitro for dopamine(DA) neuronal uptake inhibitionMore data for this Ligand-Target Pair
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Institut National de Recherche Agronomique (INRA)-Vetagro Sup, Veterinary School of Lyon
Affinity DataIC50: 8.80nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Binding affinity to human serum albumin at 20 degC by isothermal titration calorimetry analysisMore data for this Ligand-Target Pair
Affinity DataKd: 5.50E+3nMAssay Description:Binding affinity to human serum albumin assessed as dissociation rate constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 5.40E+3nMAssay Description:Binding affinity to low-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 9.00E+5nMAssay Description:Binding affinity to high-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 5.10E+5nMAssay Description:Binding affinity to high-affinity binding site of human serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: 9.31E+3nMAssay Description:Binding affinity to Wistar rat serum albuminMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+4nMAssay Description:Binding affinity to low-affinity binding site of rat serum albumin at 20 degC by surface plasmon resonance assayMore data for this Ligand-Target Pair