null

SMILES COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2cccnc2)cc1

InChI Key InChIKey=XDHJBIYJRNFDKS-IBGZPJMESA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 10351   

TargetCaspase-3(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataKi:  4.40nM IC50: 3.90nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40SDNPubMed
TargetCaspase-1(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40SDNPubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 3.89nMAssay Description:Inhibition of caspase3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VTJPubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40SDNPubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataEC50:  450nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB176GPubMed
TargetCaspase-7(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 15.1nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40SDNPubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University School of Medicine

LigandPNGBDBM10351(1-(4-Methoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors. The amount of AMC released was determined by using a ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40SDNPubMed