null

SMILES Nc1c(F)cc(cc1Cl)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O

InChI Key InChIKey=HOLJYLOVIHBQHO-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 11625   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 13(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  0.900nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8CR9PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6JRWPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53M44PubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5P89PubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
University of Agricultural Sciences and Veterinary Medicine

LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8CR9PubMed
TargetCarbonic anhydrase(Astrosclera willeyana)
Slovak Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5P89PubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Inhibition of human recombinant carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant carbonic anhydrase 5b after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant carbonic anhydrase 5a after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 15(Mus musculus)
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of mouse recombinant carbonic anhydrase 15 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8CR9PubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Inhibition of human recombinant carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 3(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XCBPubMed
TargetCarbonic anhydrase 3(Homo sapiens (Human))
University of Florida

Curated by ChEMBL
LigandPNGBDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)copy SMILEScopy InChI
Affinity DataKi:  8.05E+4nMAssay Description:Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NJ9PubMed