null
SMILES Clc1cccc(Cl)c1-c1nc2ccnc(NC(=O)C3CC3)c2s1
InChI Key InChIKey=OMYNARKMWCXCMB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 120128
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche AG
US Patent
F. Hoffmann-La Roche AG
US Patent
Affinity DataKi: 0.5nM ΔG°: -12.6kcal/molepH: 7.2 T: 2°CAssay Description:To determine the inhibition constants (Ki) of Examples 1-240, compounds were diluted serially in DMSO and added to 50 μL kinase reactions contai...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
F. Hoffmann-La Roche AG
US Patent
F. Hoffmann-La Roche AG
US Patent
Affinity DataKi: 0.5nMAssay Description:Inhibition of TYK2 (unknown origin) assessed as reduction in IL-23 induced STAT3 phosphorylation by cell based ELISAMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of JAK2 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair