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SMILES COc1ccc(cc1OC1CCCC1)C1(CCC(CC1)C(O)=O)C#N

InChI Key InChIKey=CFBUZOUXXHZCFB-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 14773   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(RAT)
University of Tennessee

Curated by PDSP Ki Database
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataKi:  118nMMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(RAT)
University of Tennessee

Curated by PDSP Ki Database
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 8.70E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [531-875](Homo sapiens (Human))
Plexxikon

LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase [574-941](Homo sapiens (Human))
Plexxikon

LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+5nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 8.70E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed
LigandPNGBDBM14773(4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclo...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00Q1PubMed