null

SMILES C[C@H](Nc1cc(ccn1)-c1c(nc(C2CCNCC2)n1C)-c1cccc(c1)C(F)(F)F)c1ccccc1

InChI Key InChIKey=ZLQKJFNLHHGAQF-IBGZPJMESA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 15459   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28050V6PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81C8DPubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81C8DPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 810nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81C8DPubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of JNK2alpha1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37X67PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81C8DPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type p38alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44Q2FPubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type p38beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44Q2FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 810nMAssay Description:Inhibition of human c-RAF at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37X67PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGF receptor kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81C8DPubMed