null
SMILES CCCCNNC(=O)c1ccc(OC)cc1
InChI Key InChIKey=RFMNSSZOADXOBU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 163623
TargetHistone deacetylase 1/Nuclear receptor corepressor 2 [395-498](Homo sapiens (Human))
University of Florida College of Medicine; Northwest Agriculture and Forestry University
University of Florida College of Medicine; Northwest Agriculture and Forestry University
Affinity DataIC50: 1.91E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 [395-498](Homo sapiens (Human))
University of Florida College of Medicine; Northwest Agriculture and Forestry University
University of Florida College of Medicine; Northwest Agriculture and Forestry University
Affinity DataIC50: 430nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ...More data for this Ligand-Target Pair
Affinity DataIC50: 157nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
Affinity DataIC50: 1.91E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
Affinity DataIC50: 2.52E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central —C(O)—NH—NH— unit flanked by a phenyl group and a short aliphatic...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 157nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
Affinity DataIC50: 727nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
University of Florida Research Foundation, Inc.; The Scripps Research Institute
US Patent
TargetHistone deacetylase 2/Nuclear receptor corepressor 2 [395-498](Homo sapiens (Human))
University of Florida College of Medicine; Northwest Agriculture and Forestry University
University of Florida College of Medicine; Northwest Agriculture and Forestry University
Affinity DataIC50: 2.52E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395¿498)) were obtained from BPS ...More data for this Ligand-Target Pair