null

SMILES OC(=O)CCc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1

InChI Key InChIKey=VRORTNGXAKZJML-UHFFFAOYSA-N

PDB links: 22 PDB IDs contain this monomer as substructures. 10 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 18864   

TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio AB

LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 0.0410nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K26TGPubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio AB

LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 0.0190nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K26TGPubMed
TargetSolute carrier family 12 member 5(Homo sapiens (Human))
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataEC50:  5.39E+3nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3CSCPCBioAssay
TargetSolute carrier family 12 member 5(Homo sapiens (Human))
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataEC50:  1.11E+4nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q52N1XPCBioAssay
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetProliferating cell nuclear antigen(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarizat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ12CZPubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio AB

LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 0.0191nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0HD8PubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Karo Bio AB

LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 0.0407nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XJQPubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Karo Bio AB

LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 0.0191nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XJQPubMed
TargetSolute carrier family 12 member 5(Homo sapiens (Human))
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataEC50:  4.25E+3nMAssay Description:Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Assay Provider: Eric Delpire Assay Provider Affliation: Vanderbilt University Gr...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M32T6MPCBioAssay