null
SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(CO)c2)ccc1O
InChI Key InChIKey=UAVJPMNEDOIHEI-YPCIICBESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 191763
Affinity DataIC50: 8.20E+3nMAssay Description:The NF-kB activities of curcumin and analogs were determined by a cellular firefly luciferase assay. This assay utilized a commercially available cel...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 1.40E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 2.90E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 8.50E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 1.10E+5nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 1.40E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 1.10E+5nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 8.50E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 1.10E+5nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 1.40E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 2.90E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 8.50E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
The Research Foundation of State University of New York; Chem-Master International, Inc.
US Patent
Affinity DataIC50: 2.90E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair