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SMILES CN(C)CCn1c2CC(C)(C)Cc3n[nH]c(=O)c4cccc1c4c23

InChI Key InChIKey=XPCCVBMKWOBTFC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 207583   

TargetPoly [ADP-ribose] polymerase 1(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3KBDUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QV3KBDUS Patent
TargetPoly [ADP-ribose] polymerase 1(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN75ZVUS Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+6nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CN75ZVUS Patent
TargetPoly [ADP-ribose] polymerase 1(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+6nMAssay Description:Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent
TargetPoly [ADP-ribose] polymerase 1(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataEC50:  4.90nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PARP-2 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474FGFPubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
BeiGene, Ltd.

US Patent
LigandPNGBDBM207583(US10501467, Example 28 | US9260440, 28 | US9617273...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89FS5US Patent