null
SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1
InChI Key InChIKey=GOAZOFMNXDONAU-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 207990
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 180nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 150nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 1.60E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 8.00E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 64nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
In DepthDetails
TargetSerine/threonine-protein kinase WNK3 [1-434](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 377nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK4 [1-444](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 187nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
Curated by ChEMBL
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
Curated by ChEMBL
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States.
Curated by ChEMBL
TargetSerine/threonine-protein kinase WNK2 [166-489](Homo sapiens (Human))
Novartis Institutes for BioMedical Research, Inc.
Novartis Institutes for BioMedical Research, Inc.
Affinity DataIC50: 50nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair