null

SMILES Cc1c(nn(c1-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1

InChI Key InChIKey=BUZAJRPLUGXRAB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 21279   

TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute on Drug Abuse

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Binding affinity was determined by using a competition assay with [125 I]- AM251 against rat cannabinoid receptor 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M079XPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GX48V9PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53MSNPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8GHDPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]CP-55,940 from recombinant human CB1 receptor transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z15T3PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN15XRPubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute on Drug Abuse

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Inhibition of [3H]-CP-55,940 binding to cannabinoid receptor 1 in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222T3ZPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  7.49nMAssay Description:Binding affinity to cannabinoid CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6QPFPubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute on Drug Abuse

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  7.49nMAssay Description:Binding affinity against Cannabinoid receptor 1 in rat forebrainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2FZVPubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute on Drug Abuse

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  7.5nMAssay Description:Activity at beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  7.5nMAssay Description:Antagonist activity at CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8X4M
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  7.5nMAssay Description:Antagonist activity at CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8X4M
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  69nMAssay Description:Displacement of [3H]JWH-018 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60SD8PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C53MSNPubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  112nMAssay Description:Displacement of [3H]CP-55,940 from recombinant human CB2 receptor transfected in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z15T3PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  112nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibition c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GX48V9PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  112nMAssay Description:Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8GHDPubMed
TargetCannabinoid receptor 2(MOUSE)
University of Connecticut

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  2.29E+3nMAssay Description:Binding affinity against Cannabinoid receptor 2 in mouse spleenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2FZVPubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
National Institute on Drug Abuse

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  2.29E+3nMAssay Description:Activity at beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetCannabinoid receptor 2(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataKi:  2.29E+3nMAssay Description:Binding affinity to cannabinoid CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6QPFPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataEC50:  68nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in Sf9 cells coexpressing Gbeta1gamma2 and RSG4 assessed as degradation of [gamma-33P]GTP af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M38HVPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Displacement of [3H]CP-55940 from human wild type CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KDRPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataEC50:  58nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in Sf9 cells coexpressing Galpha i2 assessed as Galpha GTPase activity using [gamma-33P]GTP ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862J3WPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataEC50:  70nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in Sf9 cells coexpressing Gbeta1gamma2 and RSG4 assessed as degradation of [gamma-33P]GTP af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M38HVPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Sapienza Universitāadi Roma

LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.320nMAssay Description:Displacement of [3H]SR-141716 from human wild type CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KDRPubMed