null
SMILES OC(=O)CNC(=O)C(CS)Cc1ccccc1
InChI Key InChIKey=LJJKNPQAGWVLDQ-UHFFFAOYSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 21641
Affinity DataKi: 4nM ΔG°: -11.9kcal/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 4.70nMAssay Description:Compound was evaluated for inhibition of recombinant human neprilysin(NEP).More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Binding affinity towards enkephalinase (metalloendopeptidase, E.C.3.4.24.11) of rat kidneyMore data for this Ligand-Target Pair
Affinity DataKi: >100nMAssay Description:Specific activity of ACE was assayed in black 96-well microplates with or without various concentrations of inhibitors. N-Cbz-Phe-His-Leu was added, ...More data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
Affinity DataKi: 1.81E+3nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:ECE activity was performed in black 96-well microplates with recombinant human ECE-1c (hECE-1c). The hECE-1c was preincubated with or without increa...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Theravance Biopharma US Inc.
Curated by ChEMBL
Theravance Biopharma US Inc.
Curated by ChEMBL
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of Europium-labeled angiotensin-2 from human AT1 receptor expressed in CHOK1 cell membranes after 120 mins by DELFIAMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nM IC50: 1.00E+5nMAssay Description:Inhibitory assay against ECE-2.More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration was evaluated by Inhibiting 50% of Neutral endopeptidase enzyme (NEP) activity using 20 nM [3H]-D-Ala2-Leu-enkephalin as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Tested in vitro for the inhibition against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibitory concentration was evaluated by Inhibiting 50% of Angiotensin I converting enzyme activity using 50 microM N-Cbz-Phe-His-Leu as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human NEP-mediated amyloid beta hydrolysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibitory concentration required to inhibit thermolysinMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP 24.11) from rat kidney cortex membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibition of neutral endopeptidase from rat kidney.More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibition of Neutral EndopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition against recombinant human Endothelin converting enzyme 1 activityMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory concentration against neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of enkephalinase purified from rat kidney.More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:In vitro inhibition of Neutral endopeptidase (NEP) enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1More data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:In Vitro inhibition of recombinant human endothelin converting enzyme-1More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of pig kidney NEP by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 316nMAssay Description:Inhibition of angiotensin I converting enzyme in silicoMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of NEP (unknown origin) preincubated for 10 mins followed by fluorogenic substrate addition and measured after 20 mins by fluorescence ass...More data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against big ET-1 of Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against Leu-enkeph of Neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Dainippon Pharmaceutical Co., Ltd.
Curated by ChEMBL
Dainippon Pharmaceutical Co., Ltd.
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:In vitro inhibitory activity against angiotensin I converting enzyme (ACE) from rabbit lungMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:The compound was tested in vitro for its inhibitory activity against Enkephalinase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMT: 2°CAssay Description:Enzyme inhibition assay using neutrol endopeptiase EC 3.4.24.11 (NEP).More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:The compound was tested for its inhibitory activity against neutral endopeptidase (EC.3.4.24.111) in rat kidneyMore data for this Ligand-Target Pair