null

SMILES COc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 264216   

TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 7nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))TBA
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.91E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))TBA
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.91E+4nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK3 [811-1124](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.91E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RG0US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 58nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076P0PubMed
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))TBA
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.91E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK1 (866 to 1154 residues) expressed in insect cells using FITC-labeled C6-KKHTDDGYMPMSPGVA-NH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5JDFPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 60nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as decrease in STAT3 phosphorylation measured after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5JDFPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5JDFPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-labeled GEEPLYWSFPAKKK-NH2 pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5JDFPubMed
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical Co., Ltd.

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent