null

SMILES COCC(=O)N1CCO[C@H](C1)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=LAUHLGUSVSJYCI-GOSISDBHSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 267935   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V.

US Patent
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H9977TUS Patent
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 256nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 268nMAssay Description:Inhibition of LYNB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V.

US Patent
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMAssay Description:Inhibition of recombinant full-length His6-tagged BTK (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated A5 peptide as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 626nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of PTK6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 169nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 123nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 214nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 331nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 73nMAssay Description:Inhibition of YES1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 571nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 232nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
MERCK SHARP & DOHME CORP.; MERCK SHARP & DOHME B.V.

US Patent
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced MIP1betaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Srms(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Department of Early Development and Discovery Sciences, MRL, Merck& Co., Inc., 126 East Lincoln Avenue, Rahway, NJ 07065, USA. Electronic address: sobhana.babu.boga@merck.com.

Curated by ChEMBL
LigandPNGBDBM267935(4-{8-amino-3-[(2R)-4-oxetan-3-ylmorpholin-2-yl]imi...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959M2WPubMed