null

SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1

InChI Key InChIKey=NBAIXBAUHIQQGF-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 42 hits for monomerid = 283216   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:To analyze LSD1 inhibitor efficacy in cells, a CD11b flow cytometry assay was performed. LSD1 inhibition induces CD11b expression in THP-1 (AML) cell...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:To analyze LSD1 inhibitor efficacy in cells, a CD11b flow cytometry assay was performed. LSD1 inhibition induces CD11b expression in THP-1 (AML) cell...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:To analyze LSD1 inhibitor efficacy in cells, a CD11b flow cytometry assay was performed. LSD1 inhibition induces CD11b expression in THP-1 (AML) cell...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD-1 activity is based on Tnne Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD-1 activity is based on Tnne Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD-1 activity is based on Tnne Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4P33PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataEC50:  3nMAssay Description:Inhibition of LSD1 in human NCI-H69 cells assessed as suppression of GRP mRNA expression incubated for 4 days by qPCR analysisMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataEC50:  4nMAssay Description:Inhibition of LSD1 in human NCI-H1417 cells assessed as suppression of GRP mRNA expression incubated for 4 days by qPCR analysisMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataEC50:  6nMAssay Description:Inhibition of LSD1 in human NCI-H1417 cells assessed as suppression of GRP mRNA expression incubated for 12 days by qPCR analysisMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
CELGENE QUANTICEL RESEARCH, INC.

US Patent
LigandPNGBDBM283216(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)copy SMILEScopy InChI
Affinity DataIC50: 100nMT: 2°CAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair