null

SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H](C)CO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O

InChI Key InChIKey=KRHJVQBHCYJAPS-KRWDZBQOSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 287077   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

US Patent
LigandPNGBDBM287077((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XK8HKQUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

US Patent
LigandPNGBDBM287077((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4DVZUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

US Patent
LigandPNGBDBM287077((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DB850WUS Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma, Inc.

US Patent
LigandPNGBDBM287077((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85B83US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM287077((S)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:The cell-based effects of FGFR inhibitors were determined by measuring inhibition of FGFR-dependent cell line growth. The cell lines SNU-16 was used ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4DVZUS Patent