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SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)[nH]n2)n1)c1ncc(F)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 294911   

TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 0.200nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CHWUS Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 0.700nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CHWUS Patent
TargetTyrosine-protein kinase JAK3 [811-1124](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 60nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CHWUS Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [888-1187](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 2nMpH: 7.5Assay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CHWUS Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3JDHUS Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [888-1187](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 2nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2CRNUS Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 60nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3JDHUS Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 2nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3JDHUS Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 0.200nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2CRNUS Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2CRNUS Patent
TargetTyrosine-protein kinase JAK3 [811-1124](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 60nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2CRNUS Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM294911(US10112907, Example 00020 | US10766894, Compound T...)copy SMILES
Affinity DataIC50: 0.700nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3JDHUS Patent