null

SMILES C[C@@H](N)c1cc(Cl)ccc1Cn1c2cc[nH]c2c(=O)[nH]c1=S

InChI Key InChIKey=BHKKSKOHRFHHIN-MRVPVSSYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 312172   

TargetMyeloperoxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q24296US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7M2NUS Patent
TargetThyroid peroxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WW7M2NUS Patent
TargetMyeloperoxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QJ7MD4US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 800nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetThyroid peroxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 890nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetMyeloperoxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataKd:  501nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))TBA
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))TBA
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD44KMPubMed
TargetThyroid peroxidase(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+3nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q24296US Patent