null
SMILES CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1
InChI Key InChIKey=CWJLAVRXVFHDSJ-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 317462
Affinity DataIC50: 14nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
3D Structure (crystal)TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
Affinity DataIC50: 8.17nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
Affinity DataIC50: 728nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PIP4K2C in human HCT116 cell lysate after 1 hr by LC-MS/MS analysis relative to controlMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human GST-tagged CLK1 expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 157nMAssay Description:Inhibition of full length human recombinant GST-tagged DYRK1B expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 136nMAssay Description:Inhibition of full length human GST-tagged PHKG1 expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of human full length recombinant GST-tagged DYRK3 expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
Affinity DataIC50: 6nMAssay Description:Inhibition of human GST-tagged CLK2 expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of TTK phosphorylation at T686 residue in human CAL51 cells after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
Affinity DataIC50: 680nMAssay Description:Inhibition of CAMKK2 in human HCT116 cell lysate after 1 hr by LC-MS/MS analysis relative to controlMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 104nMAssay Description:Inhibition of human full length GST-tagged DYRK1A expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10/8/9(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of JNK1/JNK2/JNK3 in human HCT116 cell lysate after 1 hr by LC-MS/MS analysis relative to controlMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
Affinity DataIC50: 15nMAssay Description:Inhibition of CLK2 in human HCT116 cell lysate after 1 hr by LC-MS/MS analysis relative to controlMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length recombinant GST-tagged TTK expressed in baculovirus by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
Affinity DataIC50: 549nMAssay Description:Inhibition of CLK2 in human CAL51 cells assessed as reduction in phosphorylation of SRp75 after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of TTK in human CAL51 cells assessed as decrease in phosphorylated TTK T686 levels after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using ketoconazole as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
In DepthDetails
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Signal Pharmaceuticals, LLC
US Patent
Signal Pharmaceuticals, LLC
US Patent
In DepthDetails
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 267nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair