null

SMILES Clc1cccc(C[C@H](NC(=O)c2ccccc2)C(=O)NCC#N)c1

InChI Key InChIKey=NFHCBRWUVWGFHZ-INIZCTEOSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 31970   

TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1P7RPubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataKi:  251nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1P7RPubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataKi:  251nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCathepsin K(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 3.16E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetCathepsin B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human liver cathepsin B assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin K(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed
TargetCathepsin S(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 794nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 251nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetCathepsin L2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 794nMAssay Description:Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavageMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017S3PubMed