null

SMILES OC1(NC(=O)c2ccccc2)C(=O)c2ccccc2C1=O

InChI Key InChIKey=FICSYWUBABJDHB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 32085   

TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q23XM6PCBioAssay
TargetRNA-editing ligase 1, mitochondrial(Trypanosoma brucei brucei)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.37E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P26WT9PCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20863PVPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5M71PCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.82E+4nMAssay Description:The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR4VH9PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.81E+3nMAssay Description:The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70D6BPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K48M5PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.93E+3nMAssay Description:The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25T3HWFPCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M043S8PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.99E+4nMAssay Description:The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73C2ZPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.31E+3nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BG2MCPPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X928QKPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1J08PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0S8JPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101KZPCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.87E+4nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DB806HPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K77GSPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+4nMAssay Description:The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2125R2HPCBioAssay
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataEC50: >5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z036KJPCBioAssay
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T72FVTPCBioAssay
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataEC50: >5.00E+4nMAssay Description:List of compounds to be tested: Compounds that met the active criterion of Z-score is More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N58JS6PCBioAssay
TargetSerine/threonine-protein phosphatase PP1-alpha catalytic subunit(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.90E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27M06CDPCBioAssay
TargetSerine/threonine-protein phosphatase(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 828nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9FN4PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis H37Rv)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataEC50:  1.55E+4nMAssay Description:Keywords: GFP, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, which interrupt the DnaB, RecA, a...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN14NRPCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis H37Rv)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataEC50:  1.64E+4nMAssay Description:Keywords: GFP-RecA intein, protein splicing, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, whi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DR2SX9PCBioAssay
TargetSentrin-specific protease 8(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 4.39E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3R7HPCBioAssay
TargetSentrin-specific protease 6(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.39E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1H10PCBioAssay
TargetCaspase-3(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 6.99E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RJ4GZTPCBioAssay
TargetApoptotic protease-activating factor 1(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.22E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JS9NZBPCBioAssay
TargetApoptotic protease-activating factor 1(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F18X8SPCBioAssay
TargetCaspase-9(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 6.48E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25M647FPCBioAssay
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.55E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB736GPCBioAssay
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.27E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WS8RXVPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32085(MLS000085603 | N-(2-hydroxy-1,3-diketo-indan-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 1.42E+4nMpH: 7.0 T: 2°CAssay Description:The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F769WQPCBioAssay