null

SMILES CNc1nc2c(N)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

InChI Key InChIKey=ISWTXTWJONWIEN-KQYNXXCUSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 32371   

TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL
LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)copy SMILEScopy InChI
Affinity DataKi:  2.42E+3nMAssay Description:Displacement of [3H]DPCPX (without GTP) from Adenosine A1 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2QNTPubMed
TargetHeat shock 70 kDa protein 1A(Homo sapiens (Human))
Vernalis (R&D) Ltd.

LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)copy SMILEScopy InChI
Affinity DataKi:  8.30E+3nM ΔG°:  -6.93kcal/molepH: 7.4 T: 2°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49P83PubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL
LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)copy SMILEScopy InChI
Affinity DataKi:  1.86E+4nMAssay Description:Displacement of [3H]DPCPX (with GTP) from Adenosine A1 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2QNTPubMed
TargetEndoplasmic reticulum chaperone BiP(Homo sapiens (Human))
Vernalis (R&D) Ltd.

LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)copy SMILEScopy InChI
Affinity DataKd:  7.46E+3nM Kon: >1M-1s-1pH: 7.4 T: 2°CAssay Description:SPR measurements wereperformed on BIAcore T100 instrument (BIAcore GE Healthcare), at25 C on series S NTA chips (certified) according to provider'...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R49P83PubMed
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)copy SMILEScopy InChI
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03B3XPubMed
TargetHeat shock cognate 71 kDa protein(Homo sapiens (Human))
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)copy SMILEScopy InChI
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03B3XPubMed
TargetHeat shock 70 kDa protein 1A(Homo sapiens (Human))
Vernalis (R&D) Ltd.

LigandPNGBDBM32371(adenosine-derived inhibitor (Grp78), 3 | adenosine...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1PDCPubMed