null

SMILES Nc1sc(=S)c2CN(Cc3ccccc3)CCc2c1C#N

InChI Key InChIKey=LROMJUZVIXUUQW-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 34163   

TargetBcl-2-related protein A1(Mus musculus (Mouse))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMpH: 7.0 T: 2°CAssay Description:The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N014W6PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.08E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66J6BPCBioAssay
TargetCathepsin B(Homo sapiens (Human))
PCMD

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.64E+3nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25T3HTJPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20863PVPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5M71PCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 7.34E+3nMAssay Description:The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR4VH9PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 392nMAssay Description:The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70D6BPCBioAssay
TargetCathepsin B(Homo sapiens (Human))
PCMD

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.64E+3nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2C53J7NPCBioAssay
TargetBcl-2-related protein A1(Mus musculus (Mouse))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K072NWPCBioAssay
TargetProcathepsin L(Homo sapiens (Human))
PCMD

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27D2SJCPCBioAssay
TargetCathepsin S(Homo sapiens (Human))
PCMD

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 2.14E+3nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69H02PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 4.93E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K48M5PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 502nMAssay Description:The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25T3HWFPCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 4.79E+4nMAssay Description:The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M043S8PCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 2.08E+3nMAssay Description:The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73C2ZPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 949nMAssay Description:The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BG2MCPPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.41E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X928QKPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1J08PCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 3.31E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0S8JPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 4.30E+4nMAssay Description:The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J101KZPCBioAssay
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
Sanford-Burnham Center for Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 2.74E+3nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DB806HPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 2.38E+3nMAssay Description:The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28K77GSPCBioAssay
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 4.99E+3nMAssay Description:The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2125R2HPCBioAssay
TargetProcathepsin L(Homo sapiens (Human))
PCMD

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WH2NDVPCBioAssay
TargetDual specificity protein phosphatase 1(Homo sapiens (Human))
University of Pittsburgh Molecular Library Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34163(3-Amino-7-benzyl-1-thioxo-5,6,7,8-tetrahydro-1H-th...)copy SMILEScopy InChI
Affinity DataIC50: 1.13E+3nMpH: 7.0 T: 2°CAssay Description:The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F769WQPCBioAssay