null

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(Cl)c(=O)n(C3CCCC3)c2n1

InChI Key InChIKey=YEMOJJTZJLWRNY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 370140   

LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CSGUS Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9G2VUS Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0Z4TPubMed
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:The purpose of the CDK6/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5BVDUS Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.360nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.660nMAssay Description:Inhibition of non-phosphorylated CDK4/Cyclin D3 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0Z4TPubMed
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.660nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5BVDUS Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.660nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9G2VUS Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  0.660nMAssay Description:The purpose CDK4/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CSGUS Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5BVDUS Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:The mobility shift assay electrophoretically separates the fluorescently labeled peptides (substrate and phosphorylated product) following the kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KK9G2VUS Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant full length wild-type phosphorylated CDK2/Cyclin E1 (unknown origin) expressed in baculovirus expression system assessed as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0Z4TPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer Inc.

US Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:The purpose of the CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CSGUS Patent
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)copy SMILEScopy InChI
Affinity DataKi:  53nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails