null

SMILES OC(CC1c2ccccc2-c2cncn12)C1CCC(F)(F)CC1

InChI Key InChIKey=BBYFCKZHLMMOBN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 370489   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bayer HealthCare Pharmaceuticals Corporation

LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26H4KQMUS Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bayer HealthCare Pharmaceuticals Corporation

LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataEC50:  1.32E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
NewLink Genetics Corporation

Curated by ChEMBL
LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bayer HealthCare Pharmaceuticals Corporation

LigandPNGBDBM370489(1-(4,4-difluorocyclohexyl)-2-(5H-imidazo[5,1- a]is...)copy SMILEScopy InChI
Affinity DataEC50:  79nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0QNZPubMed