null
SMILES C[C@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23
InChI Key InChIKey=FIKPXCOQUIZNHB-WDEREUQCSA-N
PDB links: 2 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 48 hits for monomerid = 374727
Affinity DataKd: 0.0820nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataKd: 0.0820nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Affinity DataKd: 5.70nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 107nMAssay Description:Inhibition of SRC phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ALK L1196M (unknown origin)More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of EML4/ALK phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ALK G1202R (unknown origin)More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of EML4/ALK G1202R mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as antiproliferative activity after 72 hrs by Cell Tite...More data for this Ligand-Target Pair
Affinity DataIC50: 6.96nMAssay Description:The kinase inhibition IC50 was determined at Reaction Biology Corporation (www.reactionbiology.com, Malvern, Pa.) following the procedures described ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 5.29nMAssay Description:The kinase inhibition IC50 was determined at Reaction Biology Corporation (www.reactionbiology.com, Malvern, Pa.) following the procedures described ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.04nMAssay Description:The kinase inhibition IC50 was determined at Reaction Biology Corporation (www.reactionbiology.com, Malvern, Pa.) following the procedures described ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.830nMAssay Description:Inhibition of human TRKA using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human wild type ALK using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.170nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human pooled liver microsomes using phenacetin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of CYP2C9 in human pooled liver microsomes using diclofenac as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of CYP2C19 in human pooled liver microsomes using S-mephenytoin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.85E+4nMAssay Description:Inhibition of CYP2D6 in human pooled liver microsomes using dextromethorphan as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human pooled liver microsomes using midazolam and testosterone as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human TRKB using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate in presence of ATP by radiometric HotSpot kinase assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
University of Arkansas for Medical Sciences
Curated by ChEMBL
University of Arkansas for Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Compound was evaluated for its binding affinity against NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataKd: 5.70nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair