null

SMILES CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=AMADCPJVPLUGQO-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 384117   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
Incyte Corporation

LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
Incyte Corporation

LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
Incyte Corporation

LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 47nMMore data for this Ligand-Target Pair
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataKd:  49nMMore data for this Ligand-Target Pair
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JS9VC6PubMed
LigandPNGBDBM384117(1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)copy SMILEScopy InChI
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair