null

SMILES COc1cc(\C=C\C(=O)C(C(=O)CO)C(=O)\C=C\c2ccc(O)c(CO)c2)ccc1O

InChI Key InChIKey=BOSYBSXTFKWEEZ-KBXRYBNXSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 445058   

TargetNeutrophil collagenase(Homo sapiens (Human))
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

US Patent
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

US Patent
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

US Patent
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent
TargetCollagenase 3 (MMP13)(Homo sapiens (Human))TBA
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

US Patent
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

US Patent
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

US Patent
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F47T2HUS Patent
TargetCollagenase 3 (MMP13)(Homo sapiens (Human))TBA
LigandPNGBDBM445058(US10669227, Compound 1 | US11608309, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5X14US Patent