null
SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
InChI Key InChIKey=VOPNWXZDJKCCRE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 4626
Affinity DataIC50: 1.00E+5nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of EGF-stimulated proliferation of KB cells in cultureMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of VEGFR3 by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of Aurora B by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of insulin receptor by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of human EGFR after 1 hr using [gamma-32P]ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Univ. Lille
Curated by ChEMBL
Univ. Lille
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of TIE2 by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of Aurora A by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of PDGFRbeta by virtual HTS assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Univ. Lille
Curated by ChEMBL
Univ. Lille
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of VEGFR2 by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of EphB4 by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of ErbB2 by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR by virtual HTS assayMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Univ. Lille
Curated by ChEMBL
Univ. Lille
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant human VEGFR-2-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for its concentration required to inhibit the rat liver F16BPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate by scintillation counting in presence ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Rajiv Gandhi Proudyogiki Vishwavidyalaya
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR (unknown origin) using biotinylated-PTP1B (Tyr66) as substrate incubated for 5 mins prior to substrate addition measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Inhibition of human EGFR expressed in human A431 cells using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Univ. Lille
Curated by ChEMBL
Univ. Lille
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of EGF-stimulated proliferation of KB cells in cultureMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR isolated from human A431 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:In vitro inhibitory effect of histamine H3 antagonist on the electrically evoked contractile response of isolated guinea pig jejunum segments.More data for this Ligand-Target Pair
In DepthDetails
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Univ. Lille
Curated by ChEMBL
Univ. Lille
Curated by ChEMBL
Affinity DataIC50: 800nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair