null

SMILES COc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O

InChI Key InChIKey=BVSLRGAPRGQWNC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 463447   

TargetMelatonin receptor type 1B(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03CZJPubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24Q7Z44US Patent
TargetMetallothionein-2(Human)
ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A.

US Patent
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3Q7QUS Patent
TargetMelatonin receptor type 1A(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24Q7Z44US Patent
TargetMelatonin receptor type 1A(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3Q7QUS Patent
TargetMelatonin receptor type 1A(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03CZJPubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataEC50:  0.0630nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by Hi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03CZJPubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataEC50:  0.860nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03CZJPubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))TBA
LigandPNGBDBM463447(US10781182, Compound IA2-143 | US11091445, Compoun...)copy SMILEScopy InChI
Affinity DataEC50:  0.25nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spec...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03CZJPubMed