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SMILES [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](-[#7])=O
InChI Key InChIKey=ADNPLDHMAVUMIW-CUZNLEPHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 69 hits for monomerid = 50001450
TargetSubstance-P receptor(Rattus norvegicus (rat))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetSubstance-P receptor(Rattus norvegicus (rat))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetSubstance-P receptor(Rattus norvegicus (rat))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetSubstance-P receptor(Rattus norvegicus (rat))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataKi: 1.10nMAssay Description:Ability to inhibit the binding of [125I]physalaemin to the SP receptors in rat telencephalon slicesMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataKi: 1.60nMAssay Description:Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
TargetEledoisin(Eledone moschata (Musky octopus) (Ozaena moschata))
National Institutes of Health
Curated by PDSP Ki Database
National Institutes of Health
Curated by PDSP Ki Database
TargetClass E basic helix-loop-helix protein 22(MOUSE)
National Institutes of Health
Curated by PDSP Ki Database
National Institutes of Health
Curated by PDSP Ki Database
Affinity DataKi: 51nMAssay Description:Evaluated for the binding affinity against NK1 receptorMore data for this Ligand-Target Pair
TargetSubstance-K receptor(Homo sapiens (Human))
Creighton University School of Medicine
Curated by ChEMBL
Creighton University School of Medicine
Curated by ChEMBL
Affinity DataKi: 102nMAssay Description:The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2More data for this Ligand-Target Pair
TargetSubstance-K receptor(Homo sapiens (Human))
Creighton University School of Medicine
Curated by ChEMBL
Creighton University School of Medicine
Curated by ChEMBL
TargetNeuromedin-K receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
TargetProthrombin(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by PDSP Ki Database
Schering-Plough Research Institute
Curated by PDSP Ki Database
Affinity DataKi: >3.00E+4nMAssay Description:Ability to inhibit the binding of [3H]N6-phenylisopropyl adenosine to adenosine receptor in rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetMas-related G-protein coupled receptor member X2(Homo sapiens (Human))
University of North Carolina
University of North Carolina
Affinity DataEC50: 1.10E+3nMpH: 7.4 T: 2°CAssay Description:MRGPRX2 stable cells were maintained in DMEM containing 10% FBS, 100 μg/ml hygromycin B, and 15 μg/ml blasticidin. For the calcium mobiliza...More data for this Ligand-Target Pair
TargetMas-related G-protein coupled receptor member X2(Homo sapiens (Human))
University of North Carolina
University of North Carolina
Affinity DataEC50: 5.10E+3nMpH: 7.4 T: 2°CAssay Description:HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Rattus norvegicus (rat))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 0.120nMAssay Description:Inhibition of Tachykinin receptor 1 of rat forebrain tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 717nMAssay Description:Inhibitory activity against binding of [125I]-[MePhe7]-NKB SP to tachykinin NK-3 receptor in guinea pig cortical membranes.More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleMore data for this Ligand-Target Pair
Affinity DataEC50: 167nMAssay Description:Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeMore data for this Ligand-Target Pair
Affinity DataEC50: 4.90nMAssay Description:Agonistic activity at tachykinin receptor 1 receptor in guinea pig ileum longitudinal smooth muscleMore data for this Ligand-Target Pair
Affinity DataIC50: 148nMAssay Description:Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2More data for this Ligand-Target Pair
Affinity DataEC50: 5.60nMAssay Description:In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataEC50: 1nMAssay Description:Agonist activity at bfSPR to produce increase in intracellular [Ca2+]More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataEC50: 0.600nMAssay Description:SP-induced [Ca2+] mobilization in CHO cells expressing human Tachykinin receptor 1More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 0.120nMAssay Description:Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligandMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]BH-SP to human recombinant NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Rattus norvegicus (rat))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 0.370nMAssay Description:Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]-BH-SP as radioligandMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 0.260nMAssay Description:Inhibitory activity against binding of [125I]-Bolton-Hunter SP to tachykinin NK-1 receptor in human lymphoma IM9 cells.More data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 0.610nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 0.240nMAssay Description:Compound was evaluated for the antagonistic activity against NK1 receptorMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Rattus norvegicus (rat))
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Sanofi-Synthélabo Recherche
Curated by PDSP Ki Database
Affinity DataIC50: 0.120nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
TargetNeuromedin-K receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
SmithKline Beecham Pharmaceuticals
Curated by PDSP Ki Database
Affinity DataIC50: 125nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair