null
SMILES C1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
InChI Key InChIKey=UKUVHVSOTZPZBW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50001536
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
Affinity DataIC50: 13.1nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataIC50: 6.53E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) using histone H1 as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair