null
SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O
InChI Key InChIKey=UQCNKQCJZOAFTQ-ISWURRPUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50001707
Affinity DataKi: 0.540nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Inhibitory binding constant in guinea pig brain homogenate was reported at mu site at a temperature 25 degree Centigrade labeled with [3H](D-Ala2-MeP...More data for this Ligand-Target Pair
Affinity DataKi: 0.970nMAssay Description:Inhibition of [3H]DAMGO binding to opioid receptor mu from rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5.01nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Binding affinity against Opioid receptor mu 1 of guinea pig brain membranes using 0.5 nM of [3H]naloxone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 17.4nMAssay Description:Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 23.1nMAssay Description:Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of [3H]-HS665 from recombinant human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 26.2nMAssay Description:Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293More data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor delta 1 at a a temperature 25 degree Celsius labeled with ...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataKi: 57.6nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum homogenate by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataKi: 61.6nMAssay Description:Inhibition of [3H]U-69593 binding to opioid receptor kappa from guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Displacement of [3H]-diprenorphine from recombinant human DOR expressed in CHO cell membranes after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 80.5nMAssay Description:Inhibition of [3H][Ile5,6]deltorphin II binding to opioid receptor delta from rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 95nMAssay Description:Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataKi: 137nMAssay Description:Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor kappa 1 at temperature 25 degree Celsius labeled with (-)-...More data for this Ligand-Target Pair
Affinity DataKi: 145nMAssay Description:Binding affinity against Opioid receptor delta 1 of guinea pig brain membranes using 1 nM of [3H]DADLE as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 208nMAssay Description:Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 435nMAssay Description:Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 610nMAssay Description:Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 724nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataKi: 725nMAssay Description:Binding affinity against Opioid receptor kappa 1 of guinea pig brain membranes using 1 nM of (-)-[3H]ethylketazocine as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 730nMAssay Description:Displacement of [3H]- diprenorphine from delta-receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Binding affinity to opiate receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Affinity DataEC50: 7.80nMAssay Description:Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Kitasato University
Curated by ChEMBL
Kitasato University
Curated by ChEMBL
Affinity DataIC50: 630nMAssay Description:Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of Opioid receptor delta 1 by displacing 1 nM [3H]DPDPE in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Medicine Greifswald
Curated by ChEMBL
University Medicine Greifswald
Curated by ChEMBL
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Rattus norvegicus (rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 0.150nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Rattus norvegicus (rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 0.0130nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair