null

SMILES CN1CCCC1c1cccnc1

InChI Key InChIKey=SNICXCGAKADSCV-UHFFFAOYSA-N

PDB links: 20 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 86 hits for monomerid = 50004108   

TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  0.840nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  0.840nMMore data for this Ligand-Target Pair
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  0.960nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1VF8PubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q237777NPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]-MLA binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membraneMore data for this Ligand-Target Pair
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HH6HKJPubMed
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  1.05nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  1.26nMAssay Description:Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  1.5nM ΔG°:  -12.0kcal/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of [3H](-)-nicotine binding to rat brain (minus cerebellum) Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  3.60nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99PVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  4.60nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  4.90nMMore data for this Ligand-Target Pair
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Binding affinity to human alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7N96PubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  5.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6P3DPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  7.22nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JGJPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  7.70nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  8.30nMMore data for this Ligand-Target Pair
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  8.90nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9FPKPubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  9.40nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280648PubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1VF8PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9PQXPubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9PQXPubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Sanofi-Synthelabo Research

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM85WXPubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0D27PubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  22nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2222S97PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  26.3nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University of Florida

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  35nMAssay Description:Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  40nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XG9PQXPubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  55.2nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280648PubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  55.3nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280648PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  74nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
The Danish University of Pharmaceutical Sciences

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  83nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99PVPubMed
TargetAcetylcholine-binding protein(Lymnaea stagnalis)
University of Copenhagen

LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  83nMAssay Description:Binding affinities for alpha 4 beta 2 nAChR were determined in tissue suspension of rat cortical membranes using 1 nM [3H]cytisine. Binding affiniti...More data for this Ligand-Target Pair
TargetUncharacterized protein(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  98nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0D27PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)copy SMILEScopy InChI
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21C1VF8PubMed
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