null
SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2ccc(C)cc2)C1=O)c1ccccc1
InChI Key InChIKey=HWTHDEITPOXGRT-QFIPXVFZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 40 hits for monomerid = 50006878
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Displacement of [125I]CCK-26-33 from CCK2R-MOPR (unknown origin) coexpressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Capacity to inhibit [3H]-p CCK 8 binding to membrane preparations of CHO cells transfected with the rat CCK-B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Displacement of [125I]CCK-26-33 from CCK2 receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of [125I]-labeled gastrin binding to gastrin receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:In vitro binding affinity for the cholecystokinin type A receptor in guinea pig pancreas assayed using [125I]-BH-CCK-8 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of binding of [125I]CCK-8 to cholecystokinin type A receptor in rat pancreatic tissueMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of binding of [125I]-CCK-8 to the cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]-BH-CCK-8 as radioligandMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 736nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type A receptor in pancreatic tissueMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:The concentration of the compound required for half maximal inhibition of the binding to Cholecystokinin type B receptor (CCK-B) from guinea pigcorti...More data for this Ligand-Target Pair
Affinity DataIC50: 736nMAssay Description:Inhibition of ligand binding to Cholecystokinin type A receptor receptor from rat pancreatic tissue.More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Half maximal inhibition of binding of [125I]-CCK-8 to Cholecystokinin type B receptor in guinea pig cerebral cortex.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of cholecystokinin B receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Binding affinity towards Cholecystokinin type A receptor (CCK-A) receptor from rat pancreas using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Binding affinity towards Cholecystokinin type B receptor (CCK-B) receptor in mouse cerebral cortex using [125I]-Bolton Hunter CCK-8 as radioligandMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:In vitro test for inhibition of [125I]-CCK binding to Cholecystokinin type B receptor from guinea pig cortical membranes was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 736nMAssay Description:In vitro test for inhibition of [125I]-CCK binding to Cholecystokinin type A receptor from rat pancreatic tissues was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:The compound was tested for its activity to inhibit the binding of [125I]-CCK-8 to Cholecystokinin type A receptor in rat pancreasMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibitory activity of the compound against Cholecystokinin type B receptor in guinea pig cerebral cortex using [125 I ]- CCK-8 as radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 736nMAssay Description:Displacement of [125I]-BH CCK-8S from Cholecystokinin type A receptor in rat pancreasMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Displacement of [125I]-BH CCK-8S from Cholecystokinin type B receptor in guinea pig cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Binding activity towards cholecystokinin-B (CCK-B) receptor in guinea pig cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 2nMpH: 6.5Assay Description:The compound was tested for its activity to inhibit the binding of [125I]-CCK-8 to Cholecystokinin type B receptor in guinea pig brain at a pH of 6.5More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against gastrin receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against Cholecystokinin type B receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibitory activity against Cholecystokinin type A receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against gastrin receptor.More data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibitory activity against Cholecystokinin type A receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibitory activity against Cholecystokinin type B receptorMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of [125 I]CCK-8 binding to Cholecystokinin type B receptor of mouse cerebral cortexMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type A receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University of Minnesota
Curated by ChEMBL
University of Minnesota
Curated by ChEMBL
Affinity DataIC50: 5.30nMAssay Description:Inhibition of [125I]-CCK-8 sulfate binding to cholecystokinin type B receptor in mouse brain membranes.More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(MOUSE)
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Parke-Davis Pharmaceutical Research
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of [125I]-labeled CCK-8 sulfate binding to CCK-B receptor in mouse brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Binding activity towards cholecystokinin-A (CCK-A) receptor in guinea pig pancreasMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against CCK-B receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Inhibitory activity against cholecystokinin-A (CCK-A) receptor in pancreas of guinea pig.More data for this Ligand-Target Pair